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Friends View All (1) thetre…       Pinky and the Brain Premiered: Sep. 09, 1995 Network: The WB Random Fun Fact: The Brain's voice is based upon that of Orson Welles. The voice actor portraying Brain is Maurice LaMarche, who also portrayed Orson Welles by dubbing 'Vincent DOnofrio's role as Orson Welles… [show all]The Brain's voice is based upon that of Orson Welles. The voice actor portraying Brain is Maurice LaMarche, who also portrayed Orson Welles by dubbing 'Vincent DOnofrio's role as Orson Welles in the movie Ed Wood. [hide]