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Friends View All (6) dragos… lance9… thetre… vdamato harp37 dumbell     Defiance Premiered: Apr. 15, 2013 Network: SyFy Random Fun Fact: In the series the city of St. Louis is renamed Defiance. There really is a Defiance, Missouri. It is about 40 miles west of St. Louis and is where Daniel Boone settled.