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- The name of Nancy and Andy's "fakery" is Breadsticks and Scones. The cap that bakery employees wear shortens the name of the bakery to "BS" as a joke.
- Many of the exterior shots of the show are filmed on location in and around the bedroom community of Stevenson Ranch, California and Santa Clarita, California.
- The aerial photo during the intro is of Calabasas, California.
- Due to product placement deals, Nancy often carries an "It's a Grind Coffee House" beverage. A Starbucks in Calabasas, California, fills in for "It's a Grind," in the opening credits.
- The theme song "Little Boxes", was sung and composed by Malvina Reynolds in 1962.
- During the second and third seasons, the opening credits were again accompanied by the Malvina Reynolds song "Little Boxes," but sung instead by a different individual or group each time. Artists who provided covers for openers included Elvis Costello, Death Cab for Cutie, Engelbert Humperdinck, Kate McGarrigle and Anna McGarrigle (who sang the song in French), Regina Spektor, Jenny Lewis and Johnathan Rice, Randy Newman, Angélique Kidjo, Donovan, Billy Bob Thornton, The Shins, Joan Baez, The Decemberists, 'Linkin Park' and Rise Against.
- The book Rejuvenile by author Christopher Noxon has appeared several times on the show. Noxon is married to series creator Jenji Kohan. Noxon was also the music supervisor for season one and appeared in the pilot episode as a bear hunter.
- Three of the regular actors on "Weeds" share the same birthday, November 18th: Elizabeth Perkins (Celia), Kevin Nealon (Doug) and Romany Malco (Conrad).
- The fictional coastal town of Ren Mar near San Diego introduced in Season 4 gets it name from Renmar studios in Los Angeles which is where the series is shot.
- FX's The Shield is mentioned as a favorite show among some of this shows characters and several guest stars from "The Shield" have had guest appearances on this show, including U-Turn and Guillermo.
- Regular cast members Alexander Gould and Elizabeth Perkins voiced characters in Finding Nemo as title character Nemo and Coral, Nemo's mother, respectively. In season four they were joined by guest star Albert Brooks who portrays Gould's grandfather on the show but plays Nemo's father, Marlin, in 'Finding Nemo'.
- A running sound gag is heard whenever anyone (especially Nancy) is sipping a drink through a straw. The noise heard is what one would hear when a drink has gotten so low that air begins to go up the straw. This will occur in Weeds, however, regardless of the level of the liquid.
- Haley Hudson has only starred in episodes written by creator Jenji Kohan by chance.
- During season four and five, writers noticed the chemistry and enjoyment on screen between Mary-Louise Parker and Justin Kirk, so decided the Nancy/Andy dynamic by writing them more scenes together.
- Andy's obsession with Denmark and his capital comes from creator Jenji Kohan, who spent some time with her family in Denmark.
- Jenji Kohan said recently that they tried to get 'Justin Chatwin' to reprise his role as Josh Wilson several times trough the years, but he was always booked. Knowing it was their final chance, Kohan sent a text message to Chatwin directly and asked him to be on the series finale. Having done that, Chatwin appeared only in the first and final episode.
- Aside from the main cast (Mary-Louise Parker, Hunter Parrish, Alexander Gould, Justin Kirk and Kevin Nealon), Andy Milder is the only actor who appeared in every season.
- In the opening credits of this pilot episode there is no credit for Jenji Kohan as creator of the series. From the next episode on you can see the credit "created by Jenji Kohan" under the "Weeds" logo.
- When Nancy is being shown around the medical pot dispensary, there is a white board with the prices of various strains. Many of the strains are the names of other season 1 episodes.
- Paul Feig who directed this episode previously worked with Alexander Gould on his television series Freaks and Geeks. Coincidentally, Gould guest-starred in the episode "Freaks and Geeks" (1999) {Chokin' and Tokin' (#1.13)} as the kid that Lindsay is supposed to babysit when she tries marijuana for the first time.
- Writer/creator Jenji Kohan wanted Nancy to be naked in the last scene of the episode to portray how vulnerable she had made herself by sleeping with Peter. However, Mary-Louise Parker did not feel comfortable being that exposed in front of the crew.
- The episode was supposed to contain another scene in which Shane and Isabelle ride bikes through the neighborhood and Isabelle says, "My mother is horrible," to Shane who replies, "My mother is a drug dealer." Jenji Kohan debated about whether that scene or the DEA jacket scene would serve as the best ending. While Kohan thought that the bike scene was the best ending for the season, she decided that the DEA scene was the best ending for the episode.
- Peter's address number is 420.
- SPOILER: As befitting its title, the final "door closing" scene at the end of this show is a carefully crafted homage/send-up to the final scene in The Godfather.
- At one point, we see Andy reading "Rejuvenile", a book written by series creator Jenji Kohan's husband Christopher Noxon.
- Isabelle's uncredited hairstylist is played by John Paul DeJoria, co-founder and public face of John Paul Mitchell Systems.
- Peter Scottson's partner has a stomach condition - Gastroesophageal Reflux Disease and his name is Agent Fundus, which is an anatomical portion of the stomach.
- The name of the church in Majestic, the Absolute Truth Ministries, when shortened to an acronym is ATM.
- During the theme song the banner that displays the city's name Agrestic, changes to majestic because of the merging cities
- Nancy tells Shane to be a doctor, a lawyer or a business executive, which is part of the lyrics of the theme song of the other three seasons, 'Little Boxes'.
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