| C.J. Liguori | played by Dan Ziskie |
| Nick | played by James Ransone |
| James Woodrow | played by Jim True-Frost |
| Linh | played by Hong Chau |
| Mrs. Brooks | played by Venida Evans |
| Alison Myers | played by Letoya Luckett |
| Anthony King | played by Mahershala Ali |
| Lucinda | played by Meg Gibson |
| Dana Lyndsey | played by Yolonda Ross |
| Larry Williams | played by Lance E. Nichols |
| Desiree | played by Phyllis Montana LeBlanc |
| Himself | played by David Chang (VI) |
| Alcide | played by Renwick D. Scott II |
| Randall Batiste | played by Sean-Michael Bruno |
| James 'Slim Jim' Lynch | played by Spider Stacy |
| Councilman Thomas | played by Oliver Thomas (IX) |
| Robert | played by Jaron Williams |
| Judge Bernard Williams | played by Vernel Bagneris |
| Himself | played by Donald Link |
| Herself | played by Leah Chase |
| Himself | played by Jacques Morial |
| Himself | played by Harold R. Battiste Jr. |
| Sgt. Percy Bechet | played by Deneen Tyler |
| Himself | played by Coco Robicheaux |
| Himself | played by Don Bartholomew |
| Gooch | played by Nedal Yousef |
| John | played by David Kency |
| Detective Dennis Prioleau | played by John Jabaley |
| Det. Thomas Silby | played by J.D. Evermore |
| Detective Luis Calderon | played by J. Omar Castro |
| Officer Wilson | played by Lucky Johnson |
| Himself | played by Ace B. |
| Himself | played by Jon Cleary (II) |
| Herself | played by Susan Cowsill |
| Himself | played by Carl Allen |
| Himself | played by Ron Carter |
| Himself | played by Chaz Leary |
| Himself | played by Lance Ellis |
| Himself | played by Mario Abney |
| Himself | played by Cornell Williams (III) |
| Himself | played by Thaddeus Richard |
| Themselves | played by The Loose Marbles (II) |
| Themselves | played by Rosie Ledet & The Zydeco Playboys |
| Kid in Park | played by D.J. Mills |
| Bar Patron | played by Derek Killebrew |
| Voice Actor | voiced by Derrick Freeman |
| Actor | voiced by Kesha Bullard |
| Voice Actor | played by Lara Grice |