The first TV show since Nash Bridges to be filmed entirely in San Francisco.
There never has been a rooftop helipad anywhere in San Francisco.
Kevin Navayne was originally cast as Cameron Boone in the pilot, but was replaced with Derek Luke.
James D. Weston II used his Aviation training to wire the 727 cockpit for the aircraft crash scene. He is also Precision Driver Coordinator for the series.
In November 2009, Google Maps 45 degree angle mode captured the plane crash set of "Thank You" (#1.9) on its satellite imagery. People speculated that the plane shown on the set was the remains of a real plane crash and that the ambulances and firetrucks were the rescue crew saving passengers. This image can still be seen on an abandoned tarmac just south of the Oakland Naval Supply Center near Panoramic Drive in Google Maps 45 degree angle feature.