| Det. Shakima 'Kima' Greggs | played by Sonja Sohn |
| Thomas 'Herc' Hauk | played by Domenick Lombardozzi |
| Omar Little | played by Michael Kenneth Williams |
| Duquan 'Dukie' Weems | played by Jermaine Crawford |
| Maurice 'Maury' Levy | played by Michael Kostroff |
| State Sen. R. Clayton 'Clay' Davis | played by Isiah Whitlock Jr. |
| Professor Roland 'Prez' Pryzbylewski | played by Jim True-Frost |
| Judge Daniel Phelan | played by Peter Gerety |
| Off. Beatrice 'Beadie' Russell | played by Amy Ryan |
| Spiros 'Vondas' Vondopoulos | played by Paul Ben-Victor |
| The Greek | played by Bill Raymond |
| Sgt. Jay Landsman | played by Delaney Williams |
| Council President Nerese Campbell | played by Marlyne Barrett |
| Walon | played by Steve Earle |
| Lawrence Butler | played by William Joseph Brookes |
| Business Card Homeless Man | played by Ptolemy Slocum |
| Marla Daniels | played by Maria Broom |
| Executive Editor James C. Whiting III | played by Sam Freed |
| Roland 'Wee-Bey' Brice | played by Hassan Johnson |
| Melvin 'Cheese' Wagstaff | played by Method Man |
| State's Attorney Rupert Bond | played by Dion Graham |
| State Editor Tim Phelps | played by Thomas J. McCarthy (II) |
| Metro Editor Steven Luxenberg | played by Robert Poletick |
| Andy Krawczyk | played by Michael Willis |
| Rewrite Man Jay Spry | played by Donald Neal |
| Regional Affairs Editor Rebecca Corbett | played by Kara Lee Duncan |
| Mike Fletcher | played by Brandon Young (II) |
| Bill Zorzi | played by William F. Zorzi |
| Commissioner Stanislaus Valchek | played by Al Brown |
| Off. Michael 'Sanny' Santangelo | played by Michael Salconi |
| Det. Vernon Holley | played by Brian Anthony Wilson |
| FBI Supervisor Amanda Reese | played by Benay Berger |
| Bubbles' Sister | played by Eisa Davis |
| Assistant Principal Marcia Donnelly | played by Susan Duvall |
| Shardene Innes | played by Wendy Grantham |
| Off. Bobby Brown | played by Bobby J. Brown |
| Det. Christeson | played by Dennis Hill (VIII) |
| FBI Spec. Agent Terrance 'Fitz' Fitzhugh | played by Doug Olear |
| Off. Kenneth Dozerman | played by Rick Otto |
| Det. Michael Crutchfield | played by Gregory L. Williams |
| Kenard | played by Thuliso Dingwall |
| Dave Ettlin | played by Dave Ettlin |
| Spider | played by Edward Green (III) |
| 'Monk' Metcalf | played by Kwame Patterson |
| Robert Ruby | played by Stephen Schnetzer |
| Carl Schoettler | played by Carl Schoettler |
| Phil Boy | played by Sho Brown |
| Vinson | played by Norris Davis |
| Arabber | played by Reggie Alvin Green |
| Corner Boy | played by Joey Odoms |
| Ricardo 'Fat Face Rick' Hendrix | played by Troj Strickland |
| Jack Russell | played by Connor Aikin |
| Cary Russell | played by Sophia Ayoud |
| Grand Jury Prosecutor Gary DiPasquale | played by Gary D'Addario |
| Clinton 'Shorty' Buise | played by Clinton 'Shorty' Buise |
| Man | played by Henry Carter |
| Developer | played by Alan V. Poulson |
| Social Worker | played by Dionne Audain |
| Petey | played by Chris Kies |
| Officer | played by Stephen Kinigopoulos |
| Man | played by Edward C. Lewis |
| Man | played by George Smith (XXVI) |
| Johnny Weaver | played by Jeff Wincott |
| Detective | played by Michael Ahl |
| Retired Detective | played by Tom Gambrill |
| Researcher | played by Dave Ehrman |
| Detective | played by Tom Cutler |
| On-Air Reporter | played by Gina Hernandez |
| Lester Sanders | played by Tommy Lee Taylor Jr. |
| Reporter | played by Larry Carter |
| CSI Lab Tech | played by Anika C. McFall |
| Bar Patron | played by Lil Rhee |
| Whiting's Secretary | played by Jennifer Rouse |
| The Sun Copy Editor | played by Anthony Bosco |
| Boyfriend of William Rawls | played by Ted Borodaeff |
| Lawyer | played by Kristine Cornils |
| Sun Staff Member | played by Rebecca Corbett |
| Reporter | played by Art Hall |
| Reporter | played by Patrick Michael Strange |
| Banquet Attendee | played by Thomas W. Stewart |
| Deli Delivery Boy | played by Al Sotto |
| Carcetti Detail | played by Ben Solenberger |
| Sun Staff Member | played by David Simon (II) |
| Frog | played by Gary 'D. Reign' Senkus |
| District Commander | played by Karl Otter |
| Baltimore Police Officer | played by Stefan Niemczyk |
| Homicide Detective | played by Douglas Nelson (IV) |
| Police Officer | played by Marcus LaRon |
| Homicide Detective | played by Glenn Klavans |
| Homicide Secretary | played by Katrinka Stringfield |