John Kricfalusi (and, by extension, his company Spumco) left the series in 1993 over disagreements with Nickelodeon regarding content. Games Animation took over the production, and Billy West inherited the role of Ren.
Very little of the music used on the show was composed specifically for it; most of the music was compiled from stock recordings of various classical compositions, the works of jazz composer Raymond Scott (whose works are often used as background music for cartoons), and vintage "mood music" tracks from the library of British production music company KPM (composed in the '50s and '60s by such people as C. King Palmer, Laurie Johnson and Jack Beaver).
According to episodes like "Mad Dog Hoek", "Visit to Anthony" and "Stimpy's Fan Club", Ren and Stimpy live in beautiful Hollywood, Yugoslavia.
The theme song's title is "Dog Pound Hop".
"Dog Pound Hop", the theme song of the cartoon, was written and performed by some of the animation team at Spumco.
Billy West was the only voice actor to be in every episode.
John Kricfalusi originally wanted Ren and Stimpy to be featured as characters in a variety show he named "Cartoon Cavalcade".
Nickelodeon did not care for George Liquor and vetoed a majority of his proposed appearances in Ren and Stimpy. When Spumco was fired from the show, Nickelodeon had no desire to show Liquor again and sold the rights back to them.
In the early 1990s the series was banned in Canada by the CRTC because it did not fit MuchMusic's "music" format. It wasn't until a decade later that the series could air again in Canada on a new network, the Teletoon Network.
The first Nicktoon to have a video game based on it.
Muddy Mudskipper is a parody of the old Hanna Barbara cartoons.
Over the first shot of Hollywood, the head that rises up and down from out of nowhere is a caricature of John Kricfalusi's favorite actor, 'Kirk Douglas'.
Originally, the microphone was planned to go into Stimpy's mouth during the end of part one ("Stimpy's Big Day.") However, it seemed to remind Nick executives of a certain sexual method, so the scene was animated with the microphone going into his nose. The microphone in the mouth was never animated.
The music heard under the Gritty Kitty commercial sequence (at the supermarket with Stimpy and Mr. Horse) the underscore is "Stop Gap".
The music heard during the morning sequences on "Nurse Stimpy" is Beethoven's Sixth Symphony (the first movement).
The "Log" theme song is a spoof of the famous Slinky theme song.
This is the first time that it's known that Ren wishes for Huge Pectoral Muscles.
Here John K. is credited as Raymond Spum. The reason being because of numerous edits and artistic flaws.
The original ending of "Nurse Stimpy" was not for Ren to wake up and see Stimpy in the Maid Moron outfit, but rather to have the bed fall away, to have Ren and Stimpy landing on the backs of two bulls, as they ride off into the sunset. The executives at Nickelodeon reportedly balked at how little sense this scene made, and asked for a different ending. Later, however, this ending would be eventually be used in "Rubber Nipple Salesmen".
Stimpy and Ren were supposed to be blissfully married at the end of "Robin Hoek." Nick changed it to a more abrupt and funnier ending than it was meant to be.
The music heard during the morning sequences on "Nurse Stimpy" is Beethoven's Sixth Symphony (the first movement). This might be a reference to Fantasia.
Nick omitted a scene in "Nurse Stimpy" where Stimpy calls in Dr. Leeche to suck the blood out of Ren's head.
This episode aired the same year another version of "Robin Hood" was released in theaters - the Warner Bros. movie Robin Hood: Prince of Thieves (1991). Ironically, that same year, Disney re-released their Robin Hood animated film to videocassette (and laserdisc), labeling it as a "Disney Classic."
John Kricfalusi came up with the storyline for "Fire Dogs" in about an hour to fill the storyline deadline.
"The Littlest Giant" was made in demand by Nick execs who felt Ren shouldn't be so mean and insane.
The giants who boss Stimpy around are loosely based on Curly Howard and 'Larry Fine' of "The Three Stooges".
The Fire Chief was based on legendary adult cartoonist and animator Ralph Bakshi.
The gigantic "brainiac" aliens were designed by John Kricfalusi after a rare children's game called "Captain Quatem" which was supposed to teach kids the dangers of drugs.
The sound the Yak makes when he runs is someone shaking around a balloon full of water.