- Originally ran for only 24 episodes during the 1962-1963 TV season. In 1985 the program was revived, with new episodes designed to syndicate alongside the originals.
- The Jetsons' phone number is VENUS-1234.
- An episode of another Hanna-Barbera show, The Flintstones ("The Flintstones" (1960) {Time Machine (#5.18)}), in which the Flinstones and the Rubbles use a time machine at the Worlds' Fair to travel to the future, features a distinctly Jetson-esque 21st century.
- The character 'George Jetson' was ranked #4 in TV Guide's list of the "25 Greatest Sci-Fi Legends" (1 August 2004 issue).
- Based on the "Blondie" comic strip and series. Penny Singleton, who played Blondie in the 1940s series, was the voice of Jane Jetson.
- The Jetson clan appeared in print ads for Electrasol Dish Washer tabs and were the subject of a series of collectible tins (2004-05) . Jane also appeared in circular coupons
- The design of the Jetsons' flying car was inspired by a 1954 Ford concept car, the FX-Atmos, notable for its all-glass bubble canopy, dashboard radar screen, and jet-plane-like tail fins.
- The first program ever to be broadcast in color on ABC-TV.
- The title is based on the American Boy Scouts of America which have been helping young boys with confidence, direction and a chance to be outdoors since 1910.
- The title is based on the term for a soldier G.I. Joe. The abbreviation means "Government Issue" and the term was used for a toy, cartoon series and a movie.
- The title is based upon the often used quote from Shakespeare's play 'Hamlet': "To be or not to be."
- This was the last original episode broadcast on ABC.
- Final appearance of Orbitty. No explanation is given for his absence in the remainder of the series.
- Last show of the series.

