The character 'Bernie Mac' was ranked #47 in TV Guide's list of the "50 Greatest TV Dads of All Time" (20 June 2004 issue).
The show is shot in single-camera style with no laugh track or studio audience.
The idea for the show was originally pitched to NBC, ABC, CBS and the WB.
Production on the fourth season had to be suspended for eight weeks in order to allow Bernie Mac to recover from a serious case of pneumonia.
Larry Wilmore, who created and executive produced the show, was fired by FOX during the show's second season. Reports cited that Wilmore and the network constantly clashed over the show's creative direction. FOX executives felt that the show didn't have enough laughs and were disappointed with the show's ratings in its second season while Wilmore was frustrated with FOX's treatment of the show and creative interference.
Bernie Mac was originally hesitant about doing the show for fear it would tone down his comedic style.
At one point, Bryana can be seen watching 'Between the Lions' on TV in Spanish.
The scene in which Kelly is crying and saying "I don't know what to do" and Bernie slaps him, saying "Be a man!" is a direct parody of the scene in The Godfather in which Don Vito Corleone slaps Johnny Fontaine after the same exchange.
After learning of his uncle's passing, Bernie shouts "Damn damn damn!" This is a reference to a famous scene from the TV show Good Times, in which Florida Evans shouts the same thing after her husband's funeral.