Jake Sisko was the son of the famous Starfleet Captain Benjamin Sisko and Jennifer Sisko. He chose not to join Starfleet, instead becoming a writer. He made many friends on Deep Space 9, but his closest was Nog.

In 2366 Jake was living with his parents on the USS Saratoga, where his father was First Officer. Late that year his mother died at the Battle of Wolf 359.
(DS9: "Emissary")

In 2369, Jake accompanied his father to his new posting, Deep Space 9.
(DS9: "A Man Alone")

It was discovered that Jake was tutoring Nog.
(DS9: "The Nagus")

He helped his father pilot a replica of an ancient Bajoran space vessel which Captain Sisko built, on a journey to Cardassia to prove that the Bajorans reached Cardassia.
(DS9: "Explorers")

In 2372, he accompanied his father to Earth during the Changeling scare. (DS9: "Homefront")

While on Earth, he spent time with his grandfather, Joseph Sisko.
(DS9: "Paradise Lost")

Jake played a prominent role in the war against the Dominion. After the Second Battle of Deep Space 9, Jake elected to stay behind as a front line reporter on the war.
(DS9: "Call to Arms")

Jake butted head somewhat with Weyoun, the Vorta leader of the Dominion forces aboard the station. Weyoun was disturbed by Jake's use of the word "occupation" in his reports for the Federation News Service to describe the nonaggression pact between the Dominion and Bajor and concluded that Jake was biased against the Dominion and refused to transmit his stories to the outside world for publication. When Jake insisted on freedom of the press, Weyoun smiled and replied, "Please, tell me you're not that naive."
(DS9: "A Time to Stand")

Jake joined Major Kira and Rom in forming a resistance cell on Deep Space 9. They attempted to sabotage the station.
(DS9: "Behind the Lines")
Later they were arrested, with Rom sentenced to death. Ziyal and Quark rescued them and together they took the weapons off-line, with the help of Odo, which helped lead to the retaking of Deep Space 9.
(DS9: "Sacrifice of Angels")

When Captain Sisko resigned and left Deep Space 9 after the death of Jadzia Dax and the closing of the wormhole by a Pah-wraith who entered into the body of Gul Dukat, Jake returned to Earth with his father to stay with his grandfather, Joseph Sisko.
(DS9: "Tears of the Prophets")

After an assassination attempt on his father by a Pah-Wraith cultist and a reunion with Ezri Dax, he helped his father find the Orb of the Emissary on Tyree, which reopened the wormhole, freeing the Prophets. Jake then returned with his father to Deep Space 9,
(DS9: "Shadows and Symbols")

where he remained until the conclusion of the war.