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Ishka was never a typical Ferengi female. She defied almost every tenet of Ferengi philosophy and law regarding women; she wore clothes, spoke to strangers, and refused to chew her children's food (Although she sometimes offered to "pre-chew" Quark's food as a gesture of compassion.)

(DS9: "Family Business")

Later in life she made profit, left the Ferengi homeworld, and helped bring about the reformation of Ferengi society. Ultimately, she influenced Grand Nagus Zek to choose her son Rom as his successor, ensuring that her reforms would live on in the future.

(DS9: "The Dogs of War")

It was Ishka's hope that one day a Ferengi female would take her "rightful place" as Grand Nagus of the Ferengi Alliance.

(DS9: "Profit and Lace")

When it came to interacting with other people, Ishka was quite amicable and offered sound financial advice. Even while she was held prisoner by the Dominion, she had friendly conversations with the Vorta Yelgrun, informing him about such things as the importance of a diversified portfolio. However, she was also willing to stand up for herself and wasn't willing to put up with nonsense.

(DS9: "The Magnificent Ferengi")

Ishka loved her husband, who she felt was a good man, but he was unsuccessful in his commercial ventures, and while Rom inherited Keldar's heart, Quark inherited Ishka's lobes.

Rom and Ishka were very close when he was a child, and they remained close when Rom moved away from Ferenghinar; however, Ishka and Quark quarreled constantly. He did not approve of her lifestyle and resented her for earning more profit than him. Additionally, Quark believed that his father Keldar had been such a failure was because of Ishka's unorthodox ways, oblivious to her true financial genius. Nonetheless, Ishka always loved Quark, and she was still his "Moogee."

(DS9: "Family Business")

When Major Kira Nerys wanted to know why Quark was taking holopictures of her, one of the lies he told her was that he wanted to take pictures of the Promenade to send them home to his mother.

(DS9: "Meridian")

The romance between Ishka and Zek blossomed because she was willing to open his eyes to life beyond profit. When Zek was deposed temporarily, Quark became furious with Ishka, as he believed that she had been using Zek to advance her feminist agenda all along. She had been instrumental in the emancipation of females, but she maintained that Zek had made the decisions. Regardless of Ishka's motives, Quark accused her of being the worst thing that ever happened to the Ferengi Alliance. As Ishka pointed out, Zek was lonely and miserable prior to becoming involved with her. In addition to enlightening Zek's mind, Ishka was responsible for helping the Nagus' failing memory run the Alliance until their retirement to Risa together.

(DS9: "Ferengi Love Songs", "The Dogs of War")

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