Lois Lane is a fledgling journalist working for the Daily Planet and the bold, outspoken, older cousin of Chloe Sullivan. She has worked a variety of jobs over the years: campaign manager for Jonathan Kent when he ran for Kansas State Senator, chief of staff for Martha Kent when she took Jonathan's position in the State Senate, and reporter for the Metropolis Inquisitor,

Since living at the Kent Farm for most of what should have been her freshman year of college, Lois has grown quite close to the Kents, even seeing Martha Kent as the mother she never had. Her relationship with Clark Kent is full of teasing that sometimes gets the best of them; however, they also look after each other and offer each other advice.

Lois was the Maid of Honor at Chloe's wedding in November 2008. During the wedding, she started to show her feelings toward Clark and they almost shared a kiss until Lana Lang showed up and interrupted them, leaving Lois devastated. But the wedding ended disastrously when a mysterious monster kidnapped Chloe and severely injured Chloe's husband, Jimmy Olsen. Jimmy was transferred to Star City for care and Lois accompanied him, stating that she would stay with him until she heard from Chloe again. She finally returned a month later, after Lana's departure.

Since then she has got closer to the Red-Blue Blur by disguising herself as a superhero named "Stiletto" (for one episode), yet she is still unaware that her hero is Clark. She spoke to the Red-Blue Blur before he confronted Doomsday and arranged to meet with him face-to-face, but she got into a fight with Tess Mercer and found the Legion ring Clark had left behind, which transported her to an unknown time period.

Three weeks later, Lois returned with no memories of her trip other than a vivid dream.