Sela Ward was initially offered the part of Frankie. However after reading the script, Ward wanted to try out for the character of Teddy instead.
Initially Patricia Kalember commuted from New York, where her family is based, to LA to film the series. However, after three seasons the traveling became too stressful. She asked to be taken out of six shows a year, so she could handle the commute better.
Patricia Kalember's husband in real-life, Daniel Gerroll, had a recurring role in season five. He played psychiatrist Dr. David Caspian, who was counseling her character Georgie.
Sela Ward was pregnant in real-life during the fourth season. Producers chose to hide her pregnancy, rather than write it into the storyline. Ward never had to take time off from the show, as she subsequently gave birth shortly after the filming of season four was completed.
Trevor Whitsig: "Come play football with us Uncle Mitch." Uncle Mitch (Ed Marinaro): "Ah, tell ya what guys, football's really not my game." Ed Marinaro played professional football with Minnesota Vikings
This marks Ed Marinaro's final appearance as a series regular. In future seasons his character would be mentioned from time to time, but would never be seen on-camera again.
The title is based upon a quote from William Shakespeare's play "Macbeth" (Act IV, Scene I): "Double, double toil and trouble; Fire burn, and cauldron bubble."