During the introductory scenes, Rizzoli's certificate as the Honor Recruit of her class at the Boston Police Academy is shown. "Lt. Procto Krapchek" is one of the signatories.
When discussing the college experience with Rizzoli and Frost, Korsak mentions that he watched _Animal House (1978)_ a few times. Bruce McGill, who plays Korsak, starred as Daniel Simpson "D-Day" Day in _Animal House (1978)_.
Scottie Thompson was a recurring cast member for a few seasons on _"NCIS: Navel Criminal Investigative Services" (2003)_, Sasha Alexander's previous show. Scottie and Sasha don't share screen-time on either show (Scottie came on NCIS long after Sasha left).
When Jane first talks to Charles Hoyt, on his bedside table is a book by Tess Geritsen, the author whose book series inspired this show.
Detective Jane Rizzoli's middle name is Clementine.
Dr. Isles' middle name in Dorthea.
The letter the detective squad receives that begins "Dear Boss," which Rizzoli is seen holding, is a reference to a letter received the Central News Agency in London, and turned over to Scotland Yard on September 29, 1888. It begins "Dear Boss," and like the letter received by the fictional Boston police, insinuates that the Scotland Yard detectives are pursuing the wrong suspect. The writer also refers to his murders as his "work," several times, just as in the show. The 1888 letter is signed "Yours truly Jack the Ripper." This is how the name "Jack the Ripper" was coined. The detectives in charge of the investigation in 1888 suspected that the "Jack the Ripper" letter was a hoax by a reporter, though, hence addressing the Central News Agency as "Boss."
The title is taken from the Eminem and Rihanna song of the same name.