Sophia Bush admitted in an interview that she didn't feel comfortable making the love scenes with co-star Kate Mara.
Dr. Christian Troy's character was originally named Dr. Christian Vega. The name was changed when Julian McMahon was cast in the role.
In the first season, Roma Maffia's character (Liz) has the surname Winters. From season 2 onwards, her surname has changed to Cruz.
Each episode is named after a character undergoing plastic surgery in the episode.
The stereo used while performing surgery is made by Bang & Olufsen from Denmark.
In an interview at the Paley Center, creator Ryan Murphy said that the cast didn't like season 3.
The role of Sean McNamara was written specifically for Dylan Walsh.
Joely Richardson left the series in season 4 for to be with her family in England. Although she was listed as part of the main cast in the intro, she only appeared in 18 of the 41 episodes of season 5 and 6.
Ryan Murphy has admitted that he created the role of Marlowe Sawyer because he wanted to work with Peter Dinklage.
The character of Kimber was only supposed to be on the pilot, but creator Ryan Murphy liked Kelly Carlson's performance so much that keep her on the show.
With this series, Ryan Murphy wanted to explore the superficiality of plastic surgery. He initially avoided setting the show in Los Angeles because he didn't want celebrities to make guest appearances. But the practice eventually did move to LA in Season 4.
The characters are based on the lives of the writers. Many people mistake the actors for their fictional counterparts.
Liz is intended to be the conscience of the office.
Some surgery scenes had to be edited because they were just too gory. Real plastic surgeons have remarked that plastic surgery isn't as gory as this series makes it appear, but that's just for show purposes.
Gina Russo and Sofia Lopez were one-shot characters to begin with, but their roles were expanded due to their popularity.
A medical advisor approves the authenticity of all surgical procedures on the show. None of them are real, even though they often appear that way. Whenever anyone said they looked real, the makeup people were flattered.
The series has its own music video. A rare thing for a TV show.
Despite playing a plastic surgeon, Julian McMahon admits he's squeamish at the sight of blood.
During Season 1, this was the highest rated series on American basic cable, and the highest rated among the 18-49 and 25-54 age range.
SPOILER:Ryan Murphy told Bruno Campos from the beginning that Quentin Costa was going to be the Carver, so Campos could play subtlety every scene with that in mind. In fact, every time the Carver appears, Campos is wearing the costume.
Not very common for a TV series, the writing stuff remained the same during the whole show, except for Hank Chilton who joined in season 2 and Dell Chandler who worked only in the first season.
With the exception of Jennifer Salt, all the writers (Ryan Murphy, Brad Falchuk, Sean Jablonski, Hank Chilton, Lyn Greene, Richard Levine) directed episodes of the show.
Series creator Ryan Murphy's signature is on one of the documents in Christian and Sean's file when they see the advisor about splitting up their business.
Rose and Raven are conjoined twins. There have been many cases of surgeries separating twins. However, this episode has similarities to the 1991 separation of Gracie and Rosie Attard. The surgery resulted in the death of Rosie.
The DVD that contains the footage of Kiki is clearly the DVD cover of the 1995 movie 'Congo', the title is covered by Dr. Forsythe's thumb but it is quite obvious. 'Congo' also starred Dylan Walsh.
In "Nip/Tuck" (2003) {Ronnie Chase (#5.15)}, Sean mentions that this whole future sequence was actually a dream.
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