- SPOILER: The powers attained after the storm represent flaws within the characters. In season 1, Alisha, who has casual sex without regard to others, is given the power of hyper-sexual arousal. Curtis, who constantly regrets his failed athletic career, can now reverse time. Kelly, conscientious of how people saw her, has the ability to read others' minds. Simon, an introvert can now become invisible. Nathan had a "live for today" attitude and so becomes immortal.
- Karla Crome and Nathan McMullen both auditioned for other characters before being chosen to play Jess and Finn respectively. Crome originally auditioned for Curtis' love interest Nikki and McMullen, a minor villain in Series 3.
- Iwan Rheon's character Simon was originally intended to be a villain.
- Actress Lauren Socha, who portrayed Kelly Bailey in the show, was ironically given community service after a racial assault on a Taxi Driver in London.
- Joseph Gilgun's character Rudy Wade was brought in after Robert Sheehan's departure after Series 2. However, Howard Overman decided he didn't want another Nathan, so decided to make Rudy 'more emotional' which is present in the character's power of emotional induced multiplication.
- Although Howard Overman wrote a majority of the episodes, the individual actors would be allowed to discuss how their characters would act in a situation and contribute to their story lines.
- Nathan McMullen (Finn) and Joseph Gilgun (Rudy) would often tease Matt Stokoe (Alex) on set for being the only official 'Misfit' to not wear a community service jumpsuit.
- Over the course of the show's first three seasons, each character was given their own Twitter accounts, supervised by writer Howard Overman himself. Initially used for Viral Marketing, these accounts were also used to provide extra information about each character and were key to the 'Guy in the Mask' arc during the show's second series. They also bridged gaps between series' building up to the 'Vegas Baby!' and 'Erazer' spin-off short films.
- Crew members would often struggle to pronounce Iwan Rheon's first name. This got to the point that Lauren Socha refused to film a scene until they pronounced it right.
- When asked who their favorite super villain from the series was, both Nathan Stewart-Jarrett and Iwan Rheon agreed 'Tim' from the fourth episode of series 2.
- Joseph Gilgun got '23456' tattooed on to his chest in honor of his time on the series. Each number represents a different cast member from Series 3, including Matthew McNulty whose character of Seth was becoming a regular.
- Antonia Thomas was originally reluctant to take the role of Alisha Daniels due to the heavy amount of sexual activity involved in the part. However, she changed her mind when she read the script further, met with Overman and found that the character had far more depth than originally thought. Thomas also joked in an interview that when Overman met with her and asked if there were any requests for character development in Series 2 she answered "less inappropriate sexual things to do on screen."
- SPOILER: Iwan Rheon, as with most of the other cast, were disappointed with their power change in Series 3. Antonia Thomas, however, stated that she was not disappointed with the change because "her old power was shit".
- Despite rumors he left for bigger projects or because of his salary, 'Robert Sheehan' stated that he only left the series because he wanted to "piss off and do other things".
- The show was originally supposed to take place in a type of shopping centre with each of the Misfits working in a different shop on Saturdays. It was changed to the show as it is now known after E4 told Howard Overman to make it more "urban".
- Final appearance of Robert Sheehan (Nathan).
- Alisha mentions her friends Chloe, Lucy, and Emma during the infamous bottle scene story at the community center. Antonia Thomas' sisters are named Chloe-Lucy and Emma Thomas.
- The actors really had ice balls thrown at them during the hailstorm scene. Their screams of shock are real.
- The visual effect used to show Simon's invisibility power was inspired by Edvard Munch's "The Scream."
- Lauren Socha accidentally really head-butted the actress who played Jodi.
- When Nathan is at the bowling alley his stance, licking of the ball and the backing music are an almost exact copy of a scene in The Big Lebowski, in which Jesus Quintana a known pervert bowls a strike to the disgust of the main characters.
- Midway through the first series you are actually given a big clue as to Nathan's power. After Curtis changes the past and returns to the present, all of the Misfits are dead, except for Nathan. When asked how he survived, he replies "I was half dead when they found me, I'm just lucky I guess".
- The scenes in the manager office between Nathan and Bev were the first ever Misfits material shot.
- The scene with Nathan picking up the baby when he's kidnapping him took most of the day to shoot as the babies kept crying.
- SPOILER: A future version of Simon is revealed to be the confident, alluring Superhoodie in this episode. Iwan Rheon said he gained several thousand twitter followers after the episode aired.
- The "Superhoodie" scenes were shot out of sequence from the rest of the season in order to give Iwan Rheon time to get in shape for the reveal.
- Final appearance of Ruth Negga (Nikki).
- Rudy (Joseph Gilgun) makes repeated references to his disdain of Wales. Gilgun's co-star Iwan Rheon is from Cardiff, Wales.
- In this episode we meet Peter, who has the ability to control the events around him by drawing them. This may be a reference to "Simon in the Land of Chalk Drawings" a popular segment of the children's show Pinwheel.
- Contains several allusions to 2.03, where it is discovered Simon is Superhoodie. These references include: Alisha getting wounded on the same part of her forehead, Simon's touching of Alisha's face around the wound, Alisha being followed by a masked figure from above, and Simon watching the other Misfits from the roof of a building.

