- The episode titled "Love and Happy Days" (25 February 1972) was the birth of the hit show Happy Days and featured eventual cast members Ron Howard, Anson Williams and Marion Ross.
- This series had more direct and indirect spin-offs than any other American TV series. The following series can trace their roots back to this show (most via the episode "Love and Happy Days"): - "Barefoot in the Park" (1970) - Wait Till Your Father Gets Home - Happy Days - Laverne & Shirley - "Laverne & Shirley with Special Guest Star the Fonz" (1982) - Blansky's Beauties - Mork & Mindy - Out of the Blue - Fonz and the Happy Days Gang - Laverne & Shirley in the Army - The Mork & Mindy/Laverne & Shirley/Fonz Hour - Joanie Loves Chachi - New Love, American Style - and possibly others.
- The major sponsor of "Love American Style" was Oscar Mayer.
- For the shows first season the theme song was performed by the popular family group The Cowsills. For the rest of the shows run it was performed by The Charles Fox Singers who were a group of L.A. studio musicians that did many radio and television commercials.
- Flip Wilson's TV debut.
- The title is based upon a quote from William Shakespeare's play "Macbeth" (Act IV, Scene I): "Double, double toil and trouble; Fire burn, and cauldron bubble."
- Skit reunited three member's of the 'F Troop (1964)' cast, Forrest Tucker, Larry Storch and James Hampton.
- The segment "Love and the Old-Fashioned Father," starring Tom Bosley, became the seed of the series Wait Till Your Father Gets Home, which was also voiced by Bosley.
- The segment "Love and the Happy Days" was an unsold pilot. The success of American Graffiti convinced ABC to pick it up as the series Happy Days.
- Final on screen performance of Paul Ford.
- The syndicated version of the segment "Love and the Mr. and Mrs." is titled "Love and Mr. & Ms."
- Acting debut of Dr. Joyce Brothers.
- Last show of the series.
