Kay Panabaker played Emily Lightman for the pilot episode. Her one scene was opposite Tim Roth begging him not to use "covert science" on her date for the evening. After filming she was recast with Hayley McFarland. The scene was re-shot and the aired version featured McFarland. A picture of Panabaker can still be seen of Cal's desk though. Best Buy gave customers a free DVD in early 2009 with the "Lie To Me" pilot on it. This version featured Kay Panabaker in the role of Emily.
Cal Lightman was American in the original script, and Tim Roth auditioned with an American accent. It was only after he had been cast that series creator Samuel Baum decided to make the character British, so that Roth could make the part his own.
Dr. Lightman, his co-workers, and his company are all based on the real-life Dr. Paul Ekman and the Ekman Group.
The scenes filmed in the FBI's conference room were shot on a borrowed set used by another FOX series, Bones. The wood paneling and decorations are the same (particularly the little glass hexagon sitting on the back shelf).
Four actors in this episode have appeared on "Terminator: The Sarah Connor Chronicles": series regular Brendan Hines had a recurring role on "The Sarah Connor Chronicles" in season one, Karina Logue appeared in a first season episode, Barry Livingston in a second season episode and Garret Dillahunt had a starring role on the show.
Martin Walker's method of drowning and resuscitating his victims may be an allusion to recently convicted serial killer, Rodney Alcala, who repeatedly strangled and resuscitated his victims during their deaths, to prolong their agony.
In this episode, Enver Gjokai plays an Iraqi war veteran. In the show Dollhouse, which earned him a lot of exposure, he portrayed an Afghanistan vet suffering from PTSD.
After the fight with Kevin (David Rees Snell), Cal's left ear is heavily bandaged. Tim Roth played Vincent van Gogh in "Vincent & Theo"; Vincent van Gogh is known for cutting off his left ear and in his self-portrait his left ear/head is heavily bandaged.
Cal is seen wearing a Claret and Blue scarf, the colours of West Ham United - and English soccer team who Tim Roth is an avid fan of.
The song which Veronica plays in the piano by the end of the episode is called "Aguas de Marco", written by the Brazilian composer Tom Jobim. Jobim's most famous work is "Garota de Ipanema", which he once performed with Frank Sinatra.
After the last scene, when the screen turns black for the credits, a text reads "Dedicated to the loving memory of James O. Turner 1936-2010". Jamie Turner was the script coordinator for the show.