The chess game between Kai and Price in "The Game" is a move-by-move copy of an actual championship match chess game (La Bourdonnais vs. McDonnell, 1834, 21st game of the first match).
It was revealed on the Season 2 DVD that 790's fragment of human brain came from a woman.
SPOILER: The remote which Dr. Kazan uses to send Mrs. Deebee into space is a modified N64-gamepad
790 meets "award-winning author Noch Einmal" in a game show. Noch einmal is German and means "once again"
K-Town is the short name for city of Kingston, Ontario, Canada.
SPOILER: Ralph Brown is credited at the beginning of the episode but he does not appear. Instead Nigel Bennett appears without being credited at all. This was done so that even attentive viewers will be surprised when he suddenly appears out of nowhere at the end of the episode.
P4X ("Prison for Xev") is a reference to the P4W (Prison for Women) in Kingston, Ontario, Canada which was the only women's maximum security prison in Canada before it closed in 1997.