When "Hot in Cleveland" first began in early 2010, Wendie Malick, Valerie Bertinelli, and Jane Leeves were supposed to be playing characters in their late 40s. Malick was actually 59 years old approaching 60 when the show premiered.
Episodes are filmed before a live audience on Stage 19 of CBS Studio Center in Studio City, California.
Betty White's character Elka Ostrovsky was named after Howard Stern's wife Beth Ostrovsky.
In season 2 both Millicent Martin (Gertrude Moon) and Peri Gilpin (Roz Doyle) guest star in Hot in Cleveland making it a total of 4 actresses from the show Frasier.
Betty White was originally going to appear in one episode, but the producers liked her so much that they promoted her to series regular.
The script for the pilot was titled "Dead is the New 90".
At the Rock 'n' Roll Hall of Fame, Elka (Betty White) asks the bodyguard if Jay Z is there. Jay Z was the musical guest when Betty White guest hosted Saturday Night Live on May 8, 2010.
During Victoria's story of being dumped by a rock star, Melanie was referring to the Eagles' song "Take It Easy".
During the Rock & Roll Hall of Fame party, Huey Lewis' character makes a reference to drilling oil in the Gulf of Mexico. Victoria replies "still don't follow the news, do you?" This is a pun on Huey Lewis being (in actuality) the leader of his band, The News, and a reference to the 2010 BP oil spill.
At the end of the show, Elka mentions having a big crush on Liberace. In reality, Betty White and Liberace were close personal friends.
The title is based on the 1953 song "The Man that Got Away" written for the movie "A Star Is Born" by Harold Arlen and the lyrics by Ira Gershwin. In 1955 it was nominated for the Academy Award for Best Original Song and became one of Judy Garland's standard tunes.
The name of Victoria's soap opera character was Honor St. Raven.
Valerie Bertinelli's character Melanie's potential mother-in-law Agnieszka is played by Bonnie Franklin who played the role of Ann Ramono mother to Barbara Cooper played by Valerie Bertinelli in the TV show "One Day at a Time" that lasted from 1975-1984.
Valerie Bertinelli is using an EVH Eddie Van Halen Wolfgang Special Electric Guitar in Vintage White. This guitar was designed by ex-husband Edward Van Halen and named after their son, Wolfgang Van Halen.
The exterior of the bar, "Nice Buns 2", is the same set used for "Coopers" on the show, The King of Queens.
Elka mentions the Internet viral video, "The Crazy Nastyass Honey Badger," several times, including a quote from it at the end.