- Following the death of Laura Sadler who played Sandy Harper, the scriptwriters consulted her mother, Sonja Sadler, to find the most fitting way to write out the much-loved character and actress from the series. Mrs Sadler devised the storyline in which Sandy wins the lottery and secretly leaves the hospital to make a new life for herself in Australia, leaving money for her friends.
- Holby City is filmed in what used to be a BBC office at Elstree Studios: Top of the Pops staff were moved out and hospital wards were brought in.
- This was Michael Troughton's final television role before his retirement from acting.
- Final appearance of Ben Saunders (David Paisley).
- This episode was dedicated to the memory of Laura Sadler (Nurse Sandy Harper) who had died a few days earlier after falling from a balcony during a party.
- This episode had a working title of "8PM, Tuesday 2nd December 2003" and was billed with this title in the Radio Times listings magazine.
- This episode, filmed in Ghana, was made under extreme difficulties because many of the British crew were badly affected by dysentery and could not do their jobs for part of the time. During the temporary absence of the director, Hugh Quarshie (Ric Griffin) was called upon to direct some scenes.
- This story was shown as four 30-minute parts "Teacher's Pet", "Crash and Burn", "Test Your Metal" and "A Great Leap Forward" on 24, 25, 26 and 27 October 2005. The official BBC episode numbers refer to them as 20.9a and 20.9b of Casualty (UK) and 8.2a and 8.2b of Holby City, with the following week's episodes being 20.10 and 8.3 respectively. Since IMDB cannot number the Holby City episodes as 8.2a and 8.2b, they are merged here into one episode. This episode is a continuation of "Casualty" (1986) {Teacher's Pet/Crash and Burn (#20.9)}.
- When Elliot (Paul Bradley) plays a tape of the Van Morrison song "Moondance" to Gina (Gillian Bevan) as she is dying, it really is Paul Bradley and his group The hKippers who are singing/playing it.
- Final appearance of Tricia Williams (Sharon Maughan).
- The episode title is taken from the poem by Phillip Larkin which contains the notorious line "They f**k you up, your mum and dad".
- This was the first episode to have new-style credits. The names of the actors who play the regular characters were listed only in the opening titles and the actors' and characters' names for the minor and guest characters were listed only in the closing credits.
- Pachelbel's Canon was played as Faye walked up the aisle to her wedding.
- The name of the episode's director, Daikin Marsh, appeared on a board which listed the patients on the ward.
- Covers the same events as in "Holby City" (1999) {The Butterfly Effect: Part One (#12.22)} but this time seen from the point of view of Joseph (Luke Roberts) and Daisha (Rebecca Grant).
- This episode was delayed from 11 May 2010 to 12 May 2010 because of the unscheduled resignation of Gordon Brown and the accession of David Cameron as the new British Prime Minister.
- From this episode (the beginning of a new season) onwards, the credits reverted to their original design (before "Holby City" (1999) {Maria's Christmas Carol (#11.10)}) so as to list *all* the cast, in order of appearance, in the closing credits. In the interim, the main cast (but not their character names) had been listed only in the opening titles, and in a fixed order which took no account of whether the character appeared in that episode.
- The final appearance of Gerard Kelly who died of a brain aneurysm shortly after filming.
- This episode was Scottish actor Gerard Kelly's final TV role, having been recorded shortly before his death on 28th October 2010 at the age of 51.
- The names on Sahira's Cardiac Trauma Unit Support Sheet in the Holby kitchen are all real-life crew members of Holby.

