This series exists in the same fictional universe as other 'Bryan Fuller (I)' series "Wonderfalls", "Pushing Daisies" and "Mockingbird Lane". The character Gretchen Speck from the episode "Amuse-bouche" also appears in two episodes of "Wonderfalls". Also in "Wonderfalls" is the character Marianne Marie Beatle, who appears in an episode of "Pushing Daisies" and in "Mockingbird Lane".
David Tennant auditioned for the lead role of Hannibal. Bryan Fuller was so impressed with his audition, he told a magazine that even though he didn't get the role, he wanted to write Tennant a a guest role as a deranged serial killer.
In 2012, multiple sources reported that Gina Torres had been cast as the wife of the Jack Crawford character. Crawford is played by Laurence Fishburne, who is also married to Gina Torres in their real lives.