 | 1x01 A Hard Day's Night (Air Date: Mar. 27, 2005)
On the morning of her first day as a surgical intern at Seattle Grace Hospital, Meredith Grey is running late as she recovers from a one-night stand and prepares for her first day. Meredith ... |  | 1x02 The First Cut Is the Deepest (Air Date: Apr. 03, 2005)
The surgical staff tries to stay positive when a young woman, despite brain surgery, is clinging to life after a brutal attempted rape. Meanwhile, Meredith risks her spot in the intern program ... |  | 1x03 Winning a Battle, Losing the War (Air Date: Apr. 10, 2005)
On the day of a bike race, injured individuals flood into the hospital, including a pedestrian who is left brain dead. Seeing that he has no chance of ever waking up, Cristina and Izzie ... |  | 1x04 No Man's Land (Air Date: Apr. 17, 2005)
While George begins to feel that he's loosing his masculinity due to Izzie and Meredith treating him like a sister, Izzie's newest patient may loose his masculinity to prostate cancer. Cristina ... |  | 1x05 Shake Your Groove Thing (Air Date: Apr. 24, 2005)
Meredith realizes the responsibility of adulthood when her mother has to sign all of her assets over to her. Izzie decides to throw a party for her boyfriend, Hank, and the scale of the ... |  | 1x06 If Tomorrow Never Comes (Air Date: May. 01, 2005)
The interns are speechless when a woman comes in with a large, record-breaking tumor, but unfortunately for the woman, her outlook isn't good. Derek and Meredith's jobs are at risk now that ... |  | 1x07 The Self Destruct Button (Air Date: May. 08, 2005)
Derek and Meredith try to spend a night together at Meredith's, but their appearance the next morning does more harm than they expected and leads Bailey to tell Meredith to end it. Alex ... |  | 1x08 Save Me (Air Date: May. 15, 2005)
The interns treat a patient who, after a series of seizures, thinks he's gained psychic abilities. Meredith becomes dissatisfied with her relationship with Derek when she realizes that she ... |  | 1x09 Who's Zoomin' Who? (Air Date: May. 22, 2005)
When an STD breaks out, affecting several members of the staff, Webber calls a staff meeting. Later, the chief confides in Derek about his own medical concerns. Izzie and Cristina become ... |
 | 2x01 Raindrops Keep Falling On My Head (Air Date: Sep. 25, 2005)
While off from work, Meredith and Cristina discuss their mutual man problems and are interrupted when Joe, the bartender, collapses. While Webber recovers from his surgery, he appoints one ... |  | 2x02 Enough Is Enough (No More Tears) (Air Date: Oct. 02, 2005)
A family arrives at Seattle Grace after a car accident. While treating the members of the family, Alex discovers that their problems are deeper than their injuries. Meanwhile, Mrs. Webber ... |  | 2x03 Make Me Lose Control (Air Date: Oct. 09, 2005)
Meredith's secrets about the state of her mother, Ellis Grey, are revealed to the staff when Ellis is brought in for surgery. Meanwhile, secrets about Cristina's health are also reveale ... |  | 2x04 Deny, Deny, Deny (Air Date: Oct. 16, 2005)
While trying to recover, Cristina proves to be a difficult patient, and matters are made worse when her mother visits. Ellis Grey, Meredith's mother also proves to be a difficult patient ... |  | 2x05 Bring The Pain (Air Date: Oct. 23, 2005)
Meredith and Derek have to use more than their medical knowledge when a woman's strictly religious father forbids her from having an operation that would save her life. Meanwhile, George ... |  | 2x06 Into You Like A Train (Air Date: Oct. 30, 2005)
Meredith temporarily forgets her worries about Derek's decision when a train crash results in dozens of injuries. Later, Addison sees potential in Izzie, but Izzie is forced to choose between ... |  | 2x07 Something to Talk About (Air Date: Nov. 06, 2005)
The entire staff is in awe when a patient, Shane, comes in with a hysterical pregnancy while Cristina, Izzie and Meredith aggressively work on his unique case. Meanwhile, Alex is encouraged ... |  | 2x08 Let It Be (Air Date: Nov. 13, 2005)
Friends of Derek and Addison come to Seattle Grace for preemptive surgery to avoid breast and ovarian cancer. But the arrival of their friends tests Derek and Addison's professional relationship. ... |  | 2x09 Thanks for the Memories (Air Date: Nov. 20, 2005)
Thanksgiving proves to be a difficult holiday for both the interns and residents. Izzie plans a big dinner, but it doesn't look like all the invited guests will show up. Meanwhile, George ... |  | 2x10 Much Too Much (Air Date: Nov. 27, 2005)
Meredith is horrified when her one-night stand needs treatment after suffering from priapism. Meanwhile, Alex begins to frustrate Izzie and a pregnant woman carrying quintuplets stresses ... |  | 2x11 Owner of a Lonely Heart (Air Date: Dec. 04, 2005)
Cristina finds little sympathy for an inmate who purposely endangers her health to get out of serving her term in solitary confinement. Meanwhile, the interns are put in charge of watching ... |  | 2x12 Grandma Got Run Over By a Reindeer (Air Date: Dec. 11, 2005)
Burke and Cristina's differences are shown when a young boy needs a transplant but he refuses to get it. Meanwhile, the interns help Alex prepare for his exams when it's revealed that he ... |  | 2x13 Begin the Begin (Air Date: Jan. 15, 2006)
As the new year unfolds, Izzie vows to let Alex's affair go, and it comes easier when she hits it off with Denny Duquette, a heart transplant patient. George treats Bex, a teen hermaphrodite, ... |  | 2x14 Tell Me Sweet Little Lies (Air Date: Jan. 22, 2006)
Cristina and Meredith hide the truth about their relationships from each other. George is assigned to discharge an elderly patient who refuses to leave; and Alex learns the fate of his career ... |  | 2x15 Break on Through (Air Date: Jan. 29, 2006)
When the nurses at Seattle Grace go on strike, the doctors are forced to work without them. While most of the doctors cross the picket line, George refuses to cross due to his union roots. ... |  | 2x16 It's the End of the World (1) (Air Date: Feb. 05, 2006)
All morning, Meredith felt like she was in for a bad day. Her fears are realized when a medical case threatens the lives of everyone at Seattle Grace, causing officials to put the hospital ... |  | 2x17 (As We Know It) (2) (Air Date: Feb. 12, 2006)
Despite the staff doing all they can, the potentially disastrous situation continues to escalate. Meredith begins to panic about her situation, as does Derek when he's told about her circumstances. ... |  | 2x18 Yesterday (Air Date: Feb. 19, 2006)
When a person from Derek and Addison's past arrives at Seattle Grace, their now stable relationship is shaken up. Meanwhile, after visiting with her mother, Burke is told Cristina's secret; ... |  | 2x19 What Have I Done To Deserve This? (Air Date: Feb. 26, 2006)
Meredith and George fight over who gets to treat a patient. Bailey, despite being on maternity leave, treats Addison for a specific feminine problem. Izzie starts spending time with Denny, ... |  | 2x20 Band Aid Covers the Bullet Hole (Air Date: Mar. 12, 2006)
Cristina has a hard day on the job when Bailey has her take care of her baby after she gets involved in a case, despite being on maternity leave. Meredith continues to deal with the fact ... |  | 2x21 Superstition (Air Date: Mar. 19, 2006)
The doctors' superstitious sides are brought out after several deaths and strange events take place at Seattle Grace. Derek and Addison talk about a more permanent living situation, Izzie ... |  | 2x22 Name of the Game (Air Date: Apr. 02, 2006)
Derek performs brain surgery on Andrew, a young spelling bee champion who suffered a serious head injury. George, who begins to overstay is welcome at Burke's, has trouble not speaking up ... |  | 2x23 Blues for Sister Someone (Air Date: Apr. 30, 2006)
A strict Catholic mother of seven children comes to the hospital to ask Addison for medical help because her equally religious husband refuses to use condoms. Addison is able to come up ... |  | 2x24 Damage Case (Air Date: May. 07, 2006)
The interns attend to Marshall, an intern from another hospital with short-term memory loss. Marshall was also the cause of a bad accident involving a family, which leads Derek to let his ... |  | 2x25 17 Seconds (Air Date: May. 14, 2006)
Finn continues to work with Doc and is able to give his owners, Meredith and Derek, and update on his condition. George is assigned to work with Derek, while Meredith is assigned to work ... |  | 2x26 Deterioration of the Fight or Flight Response (Air Date: May. 15, 2006)
George and Izzie race to find Denny a heart as his heart gets weaker and weaker by the minute. Derek is faced with the pressure of performing surgery on one of his friends, while Cristina ... |  | 2x27 Losing My Religion (Air Date: May. 15, 2006)
After Richard learns who Derek is operating on, he tries to pump Addison for information. Callie and George have a talk about their relationship and George's true feelings. Meanwhile, Meredith ... |
 | 3x01 Time Has Come Today (Air Date: Sep. 21, 2006)
In the fallout of Izzie's decision to quit the program, the interns try to help Izzie come to terms with the death of her fiancé, Denny. Meredith is forced to decide who will be the man ... |  | 3x02 I Am a Tree (Air Date: Sep. 28, 2006)
While Burke continues to recuperate in the hospital, his parents arrive at Seattle Grace to visit and end up meeting Cristina in embarrassing circumstances. The interns, as well as Bailey, ... |  | 3x03 Sometimes A Fantasy (Air Date: Oct. 05, 2006)
Finn and Derek continue to try to outdo one another in order to win Meredith's heart. Derek woos Meredith with once in a lifetime surgeries while Finn tries his hand at a romantic hospital ... |  | 3x04 What I Am (Air Date: Oct. 12, 2006)
As Addison works with Rebecca, a pregnant woman who needs to have a C-section but wants to give birth naturally, she begins to doubt her abilities as a doctor. The interns work with Shawn ... |  | 3x05 Oh, The Guilt (Air Date: Oct. 19, 2006)
Bailey treats a young woman suffering from breast cancer while Derek begins to learn more about Addison and Mark's rekindled relationship. Meanwhile, the interns team up to defend a resident ... |  | 3x06 Let the Angels Commit (Air Date: Nov. 02, 2006)
Cristina gets the once in a lifetime opportunity to scrub in on a rare humpty-dumpty procedure, much to the envy of the other interns. Meanwhile, Alex begins to question his choice of surgical ... |  | 3x07 Where the Boys Are (Air Date: Nov. 09, 2006)
The Seattle Grace men pack up and head out to the Seattle wilderness for a camping trip. Back at the hospital, Callie and Addison work together on a pregnant patient who slipped and broke ... |  | 3x08 Staring at the Sun (Air Date: Nov. 16, 2006)
George's family comes to Seattle Grace when George's father hurts his clavicle, throwing George into a frenzy. However, George's worst fears about his father's hospital visit are realized ... |  | 3x09 From A Whisper To A Scream (Air Date: Nov. 23, 2006)
The ER is taken over by a horrific car accident and the trauma caused by the accident pushes and challenges the interns. Elsewhere, Cristina begins to wonder if she's doing the right thing ... |  | 3x10 Don't Stand So Close to Me (Air Date: Nov. 30, 2006)
Burke and Cristina's relationship continues to be strained in the aftermath of Cristina revealing Burke's limitations due to the shooting. Meredith's half-sister, Molly Thompson, is admitted ... |  | 3x11 Six Days (1) (Air Date: Jan. 11, 2007)
After George's father's heart operation, Mr. O'Malley heads back to the O.R. for another surgery for his cancer. As George continues to worry about his father, Meredith's father visits Seattle ... |  | 3x12 Six Days (2) (Air Date: Jan. 18, 2007)
Mr. O'Malley heads back to surgery in order for the doctors to operate on his cancer. Meredith deals with her emotions while her father is at Seattle Grace to visit his new granddaughter. ... |  | 3x13 Great Expectations (Air Date: Jan. 25, 2007)
While rumors about the chief's retirement begin to fly among the hospital staff, Bailey pushes for the creation of a free clinic at Seattle Grace. George uses sex as a way to cope with the ... |  | 3x14 Wishin' and Hopin' (Air Date: Feb. 01, 2007)
With Izzie's inheritance money, Bailey and Izzie open the Seattle Grace free clinic and eagerly wait for their first patient. The lives of the doctors are put at risk when a patient's blood ... |  | 3x15 Walk On Water (1) (Air Date: Feb. 08, 2007)
A horrific ferry boat accident challenges the interns, as well as the rest of the hospital staff, both physically and mentally as they all near their breaking point. Chief Webber has to ... |  | 3x16 Drowning on Dry Land (2) (Air Date: Feb. 15, 2007)
As the chaos surrounding the ferry boat accident continues, Derek frantically searches for Meredith, and is devastated when he finds her barely clinging to life. Cristina is also devastated ... |  | 3x17 Some Kind of Miracle (3) (Air Date: Feb. 22, 2007)
While Meredith's life hangs in the balance, the interns each have to grapple with the reality that she may not make it. Derek refuses to give up hope that Meredith will pull through, but ... |  | 3x18 Scars and Souvenirs (Air Date: Mar. 15, 2007)
The race for Chief of Surgery continues to heat up, especially when a new contender enters the race. Callie reveals a big secret to George, and when George ends up telling Meredith, Callie ... |  | 3x19 My Favorite Mistake (Air Date: Mar. 22, 2007)
George comes face-to-face with his father-in-law, but the circumstances of their meeting are less than perfect. Alex continues to tend to Jane Doe and helps her choose how the world will ... |  | 3x20 Time After Time (Air Date: Apr. 19, 2007)
When Izzie has to face her past, she turns to George for support and comfort. As Alex continues to work with Jane Doe, the two become more attached to each other. Meanwhile, Meredith and ... |  | 3x21 Desire (Air Date: Apr. 26, 2007)
As the interns study for and stress over their upcoming exam, the attendings suck up to the chairman of the board in order to become front runner for the Chief's position when he is admitted ... |  | 3x22 The Other Side of This Life (1) (Air Date: May. 03, 2007)
Addison, on leave from Seattle Grace, heads to Los Angeles to reconnect with old friends from med school. Back in Seattle, Meredith continues to bond with Susan, her step-mother, and Cristina, ... |  | 3x23 The Other Side of This Life (2) (Air Date: May. 03, 2007)
In the conclusion to part 1, Addison visits Los Angeles and continues to reconnect with her old medical school friends. In Seattle, Meredith gets closer to her step mother. Cristina deals ... |  | 3x24 Testing 1-2-3 (Air Date: May. 10, 2007)
The interns face one of their biggest challenges yet -- their first-year medical exams. Meanwhile, the interns must tend to three injured mountain climbers. Elsewhere, Callie becomes increasingly ... |  | 3x25 Didn't We Almost Have It All (Air Date: May. 17, 2007)
A big day arrives for all -- Cristina and Burke's wedding and the interns receive their exam results. Meanwhile, Chief Webber's replacement is named and George and Callie make a decision ... |
 | 4x01 A Change Is Gonna Come (Air Date: Sep. 27, 2007)
Meredith and Cristina return from Cristina's honeymoon to find that Burke is long gone. Izzie, Alex, Meredith and Cristina start their first day as residents, each with their own set of ... |  | 4x02 Love/Addiction (Air Date: Oct. 04, 2007)
The interns and residents treat victims of an apartment complex explosion as Alex looks into the cause of the devastating accident. Mama Burke arrives at Seattle Grace to pick up the rest ... |  | 4x03 Let the Truth Sting (Air Date: Oct. 11, 2007)
The new interns are in awe of fellow intern George's skill level, and Lexie tries to keep his "repeater" status secret. Meredith comes to Lexie's aide when Lexie is faced with her first ... |  | 4x04 The Heart Of The Matter (Air Date: Oct. 18, 2007)
Izzie reveals her true feelings for George to one of her and George's friends, and the reaction she receives is not what she expected. Meanwhile, Adele Webber rushes her niece to Seattle ... |  | 4x05 Haunt You Every Day (Air Date: Oct. 25, 2007)
It's Halloween at Seattle Grace and the day is chock-full of surprises for the doctors. Alex has a surprise visit from a former patient; Meredith thinks her mother's ashes are haunting her; ... |  | 4x06 Kung Fu Fighting (Air Date: Nov. 01, 2007)
With his marriage once again falling apart, Chief Webber invites the male surgeons out on a "gentleman's evening." Meanwhile, Cristina and Izzie compete for the same surgeries, mainly to ... |  | 4x07 Physical Attraction... Chemical Reaction (Air Date: Nov. 08, 2007)
George and Izzie's relationship is tested, as is Derek and Meredith's when Derek wants more than a physical relationship with her. Meanwhile, Mark falls for a surgeon and Callie's position ... |  | 4x08 Forever Young (Air Date: Nov. 15, 2007)
The ER is thrown into a state of chaos following a school bus accident. Meanwhile, Bailey treats her high school crush; Derek goes on a date; and Thatcher comes to Seattle Grace in search ... |  | 4x09 Crash Into Me (Part 1) (Air Date: Nov. 22, 2007)
Meredith and the Chief rush to the scene of a devastating ambulance crash in which the lives of the paramedics are at stake. Bailey treats a difficult patient and Ava returns to find Alex ... |  | 4x10 Crash Into Me (Part 2) (Air Date: Dec. 06, 2007)
In the conclusion to the two-part episode arc, Meredith races to save the life of a paramedic, who is trapped inside an ambulance. Meanwhile, the life of a patient is in Lexie's hands and ... |  | 4x11 Lay Your Hands On Me (Air Date: Jan. 10, 2008)
Bailey's family faces a medical trauma, just as her marriage is falling apart, a surprise visit from George's mother comes as a shock to both Izzie and Callie, a faith healer challenges ... |  | 4x12 Where The Wild Things Are (Air Date: Apr. 24, 2008)
Six weeks following Derek and Meredith's break-up, Derek continues to date Rose while Meredith, Alex, Izzie and Cristina compete in a surgical contest. Meanwhile, George and Lexie adjust ... |  | 4x13 Piece of My Heart (Air Date: May. 01, 2008)
Addison makes her return to Seattle Grace in order to perform an operation. As she does so, she is preoccupied by all of the changes in her former co-workers' lives. Meanwhile, Meredith ... |  | 4x14 The Becoming (Air Date: May. 08, 2008)
The nurses' outcry over McSteamy's frequent trysts leads the hospital to enact a new "date and tell" policy. Meanwhile, news about Burke's career force Cristina to cope with her feelings ... |
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