← Previous Next → 5x20 Sweet Surrender 3/5 (2 votes) First Aired: Apr. 23, 2009 on ABC Summary: Izzie bites off more than she can chew on her first day of chemotherapy, Mark and Derek are forced to work on the same patient, Meredith's plans for a simple wedding take a turn, and Karev finds himself split between worry over Izzie and excelling as a resident.

Main Characters in this Episode

• Dr. Meredi…
• Dr. Cristi…
• Dr. Alex K…
• Dr. Mirand…
• Dr. Richar…
• Dr. Callie…

• Dr. Mark S…
• Dr. Lexie …
• Dr. Owen H…
• Dr. Derek …
• Dr. Arizon…

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Guest Stars Dr. Izzie Stevens played by Katherine Heigl Dr. George O'Malley played by T.R. Knight Dr. Swender played by Kimberly Elise David Gates played by Obba Babatundé Anthony Meloy played by José Zúñiga Matt Smithson played by Elden Henson Carlos Torres played by Hector Elizondo Dr. Wyatt played by Amy Madigan Mrs. Gates played by Carlease Burke Jessica Smithson played by Mary-Charles Jones Dr. Kevin Fisher played by Regi Davis Nurse Tyler played by Moe Irvin Paramedic #1 played by Nicole Cummins Paramedic #2 played by Mac Brandt Mr. Hall played by Deacon Conroy More