Everyone except for Warren uses their real name on Sweetknuckle Junction. Warren uses Professor Ape.
Throughout the episodes, Greg's eyes change from buttons to actual eyes. The first episodes were filmed with button-eyes but because the episodes are shown out-of-order, the types of eyes alternate.
The group 'Hyperjinx Tricycle', featuring Daniel Johnston, were approached to write the theme tune. However, their song "Greg the Bunny" was rejected. It now features on their self-titled debut album.
The band Ween was approached to write the theme song for the show. They did, but it was rejected.
Greg the Bunny first appeared on a New York City public access show called "Junktape". He was then the star of interstitial short films and features on The Independent Film Channel for two years, under the show title "The Greg The Bunny Show".
The puppet for Tardy the Turtle is owned by FOX TV and as yet has not been released to the Greg The Bunny writers for future episodes.
The Susan Monster puppet is owned by Fox TV and will not be starring in the new episodes
13 episodes were made but only 11 episodes were aired. The two unaired episodes were included on the DVD.
The plot mirrors the story of Cassius Clay/Muhammad Ali: Greg/Clay is a popular public figure, Hurbada Hymena/Elijah Muhammad call this public figure into his fold and change his name (to Bizzelburp/Muhammad Ali).
The episode "Rabbit Redux" takes its name from the John Updike novel. The briefly-seen pink spot on Rochester Rabbit's face is supposed to be a melanoma from selling star maps out in the sun.
Warren goes berserk and is seen jumping up and down on a suitcase. This is a parody of a 1970s Samsonite commercial, in which the suitcase's durability was tested by being put in a gorilla cage for the ape to throw around and jump on.