Production of each half-hour episode takes ten months to a year, from concept to post-production.
The character Daria was conceived as a dry-witted comic foil to counter Beavis and Butt-head's stupidity on "Beavis and Butt-Head" (1993).
The last episode of the show's half-hour series, the fifth season's "Boxing Daria", was written to close out the show. After the creators were offered by MTV an option for another half-season (6-7 episodes) and fans begged for more, co-creator Glenn Eichler decided instead to make a 90-minute TV-movie, Is It College Yet? (2002) (TV), as the official finale.
Karen Disher modeled Brittany Taylor after Jenny McCarthy (I). Janie Mertz's inspiration for her voice was Jean Kasem from "Cheers" (1982) and "Tortellis, The" (1987).
There is a small recurring joke involving Trent writing song lyrics as he's doing something else (such as driving). He always hits a snag, needing a rhyme for an "ane"/"ame" sound, at which point somebody suggests "My soul's waves of grain" - which is a lyric first performed in a Mystik Spyral song in the second season episode "Ill". This happens both in "Camp Fear" (fifth season) and "It Happened One Nut" (third season); in the latter episode, Trent vaguely remarks, "I've heard that somewhere before."