The title and character Dangermouse were inspired by the action series "Danger Man" (1960).
While the voice of Stiletto was re-dubbed for US broadcast, changing his accent from Italian to Cockney, many of the quasi-Italian alliterations in his speech remained.
Baron Greenback's pet, Nero's sounds were made by recording David Jason laughing and talking gibberish, then speeding up the soundtrack.
In the pilot episode, Danger Mouse's arch-nemesis is introduced as "Baron GreenTeeth" (as opposed to Baron GreenBack, as he was known in later episodes).
When Dangermouse was shown in the US, the channel that screened it wanted the villain's accent to change from Italian to Cockney, because it might have offended Italian-Americans.