| Ryan Kavanaugh | played by Danny Goldring |
| Ronnie Moretti | played by Tim Decker |
| Alderman Diana Vukovich | played by Isabel Liss |
| Maggie Zajac | played by Nicole Forester |
| Ezra Stone | played by Martin Donovan (II) |
| Large Inmate | played by DuShon Monique Brown |
| I.C.U. Nurse | played by Lacy Katherine Campbell |
| Reporter #4 | played by Anita Cartagena |
| Reporter #3 | played by Kevin Cox |
| Reporter #1 | played by Tory O. Davis |
| Waiter | played by Chris Froseth |
| ER Nurse | played by Emjoy Gavino |
| City Hall Guard | played by Robert Goodwin (III) |
| Jackie | played by Mary Hollis Inboden |
| Chuck | played by Brian King (XXII) |
| Linda Driscoll | played by Elizabeth Laidlaw |
| Kane's Security | played by Rick Le Fevour |
| Kane's Aide | played by Steve Lenz |
| Phone Monkey | played by Steve Lenz |
| Adriana Mata | played by Sandra Marquez |
| Rick Mathers | played by Danny McCarthy (III) |
| Nurse | played by Kat McDonnell |
| Reporter #2 | played by Grace McPhillips |
| Kane's Driver | played by James Modzelewski |
| Staffer #2 | played by Amy Montgomery (V) |
| Corrections Officer | played by Amy C. Newbold |
| Surgeon | played by David Parkes (II) |
| Field Reporter | played by Nancy Pender |
| Ortiz | played by Richard Perez (XIII) |
| Alderman Dobbs | played by Ernest Perry |
| Miller's Assistant | played by Tyler Ross |
| Staffer #3 | played by Cyril Smith (IV) |
| Chaplain | played by Sean Sullivan (VI) |
| Alderman Alverson | played by Phillip Edward Van Lear |
| Chicago Police Officer | played by Jim Nieciecki |
| Sentinel Mail Clerk | played by Samuel Meadows |
| Sentinel Reporter | played by Babs Moran |
| Vigil Participant | played by Rob Romero |
| Chicago Alderman | played by Dillon W. Rasmussen |
| Hospital Visitor | played by Barbara Elizabeth Maleski |
| Vigil Participant | played by Barbara Elizabeth Maleski |
| Police Officer | played by Jay Delarosa |
| Chicago Police Officer | played by Jay Delarosa (III) |
| Vigil Participant | played by Nathan Geist |
| Kane's Security | played by Robert G. Beck |
| Sentinel Reporter | played by Chris D. Thomas |
| Press Photographer | played by Joel VanWambeke |
| Mayor Kane's Commander | played by Mino Mackic |
| Desk Sgt | played by Roger Wiggins |
| Nurse | played by Berdella Endress |