← Previous Next → 2x22 Mother's Day 4.71/5 (7 votes) First Aired: May. 11, 2012 on CBS Summary: Frank must race to stop a biological weapon attack on New York City, while keeping it a secret from his family during their most sentimental holiday, Mother’s Day. Meanwhile, a long-standing conflict between Danny and Jamie comes to a head.

Main Characters in this Episode

• Erin Reaga…
• Jamie Reagan
• Henry Reagan

Guest Stars Danny Reagan played by Donnie Wahlberg Frank Reagan played by Tom Selleck Jackie Curatola played by Jennifer Esposito Linda Reagan played by Amy Carlson Nicky Reagan-Boyle played by Sami Gayle Sgt. Anthony Renzulli played by Nicholas Turturro Garrett Moore played by Gregory Jbara Chief of Detectives Ed Hines played by John Rue Keith Daley played by Rodrigo Lopresti Mayor Carter Poole played by David Ramsey Anna Goodwin played by Wrenn Schmidt Undercover Detective played by Alex Ziwak Under Secretary Price played by Stewart J. Zully Reporter played by Blanchard Ryan Commuter played by Teena Byrd Reporter #2 played by Theresa Quadorozzi Traffic Agent played by Aisha De Haas Leslie - Keith's Mom played by Karen Ludwig Parishioner #1 played by Barbara Galella Detective Abigail Baker played by Abigail Hawk Priest played by Peter Mark Bockman Parishioner #2 played by Joseph A. Testa Officer Calica played by Rory Duffy Leo Packer played by Leo Fitzpatrick NYPD Chief of Intel played by David Fonteno Patrick played by Connor Gibbons Officer Mowery played by Mike Houston NYPD Police Officer played by Edward M. Kelahan NYPD Chief of Counterterrorism played by Joe Lisi Himself played by James Nuciforo NYPD Chief Surgeon played by Larry Pine Sgt. Schmidt played by Dennis Rees (II) NYPD Officer played by Stephen Sapienza NYPD Emergency Services played by Gerard Sullivan Sean Reagan played by Andrew Terraciano Jack Reagan played by Tony Terraciano Robin played by Lindsay Torrey More