- The character of Nightscream was originally intended to be a female, but was changed at the behest of the producers.
- Saban entertainment, who co-owned FoxKids at the time, created a special promotional music video for the series called "Evolution Revolution". It aired only once on the Network, and featured a clip of a frozen-in-time Cheetor, where the camera circled around him. The clip was never featured in any episode.
- Beast Machines was developed with both Full Frame and High Definition Widescreen aspect ratios.
- None of the writers on Beast Machines ever wrote for its predecessor, Beast Wars, with the notable exception of Marv Wolfman, who wrote one episode in Beast Wars' first season. Fan speculation points to this fact as one of many reasons why fans were not as receptive of Beast Machines as they were of the G1 and Beast Wars series.
- This is the only Transformers cartoon to take place entirely on their home planet of Cybertron, save for a couple of flashbacks.
- The writers were told by the producers not to watch or read any other Transformers-related media, so that they can build up the show from scratch. However they eventually disobeyed them, and started adding concepts seen in previous cartoons, tying the show strongly into the Transformers mythos.
- Since the official beast mode of Silverbolt's toy fails to represent a passable condor (with his robot feet only loosely attaching to his wings), it should not be ruled out that the original plans for the character called for him to transform into a four-legged griffin. For what it's worth, the toy does in fact look a lot better when reconfigured into such a creature.
- Writer Robert N. Skir described the show as a "religious epic novel for television".
- During the conceptualization phase, Mainframe executive Dan Didio kept assuring writer Marv Wolfman that the cartoon's predecessor, Beast Wars had very little to do with the original Transformers, with regards to continuity. This was completely untrue, and Didio's incorrect information can be seen as one of the main reasons why the Beast Machines cartoon had a somewhat loose continuity with its forerunners in the early episodes.
- Only two episodes have sunlight. Most of the events take place at night.
- When Fox Kids first put out an early description for the show as a part of its sneak-peek at 1999's fall programming, it featured a wholly different take on the basic cartoon outline, as well as some unfinished character designs. The description promised a story-telling very similar to that of its prequel, Beast Wars, with the two opposing factions being the Maximals and Predacons. The completed show differed quite a bit from this: for one, the Maximals faced off against Vehicons, and the ever-present humor of its predecessor was almost completely absent.
- Famed Transformers fiction writer Simon Furman considered the series to be too dark for children.
- The cartoon's artists and Hasbro's toy designers shared basic ideas with regards to the designs of the characters, but after a point, they separated, which resulted in a show whose characters are infamously different in appearance from the toys they represent. It is not unusual for the toys to have different shapes, colors, and even basic outlines than their in-show counterparts. Also, the characters were incredibly out of scale with each other in toy form (for instance Silverbolt, one of the tallest Maximals has the smallest toy, yet the relatively small sized Nightscream towers over his companions). Hasbro later on produced some toys that were a lot more accurate to the cartoon's depictions, although the scale issue was not resolved. Some characters, like the diagnostic drone and Botanica, who were prominently featured in the cartoon, never even had toys of their own.
- The four Maximals use the same animation models they originally did in Beast Wars, albeit with different color patterns to match the style of this show.
- The animation models of a handful of Transformers characters appear as corpses, among them Prowl and Soundwave. These are the same models as seen in "Beast Wars: Transformers" (1996) {The Agenda: Part III (#2.13)}.
- Thrust recalls memories of seeing the Maximals in their Beast Wars Third Season forms.
- The concept of the Vector Sigma computer and its key's power to turn organics into mechanical matter reaches back to _"Transformers" (1985) {The Key to Vector Sigma: Part 1} (#2.39)_ and _"Transformers" (1985) {The Key to Vector Sigma: Part 2} (#2.40)_.
- During Optimus Primal's trip into the Matrix, he sees events that happened in Beast Wars, and also the heads of his comrades' former bodies, some of which are from that show.
- SPOILER: This is the last appearance of Rhinox.
- The sequence of the surviving Maximals descending into Cybertron's core to reach the Oracle is very similar to how the scene played out in the show's pilot episode, when the Maximals first discovered the Oracle.
- The flashback that plays during Noble's recollection is the exact same footage that we saw when Nightscreem told his own tale in a previous episode.
- SPOILER: The last appearance of Jetstorm.
- The concept of the hate plague originates from "Transformers" (1984) {The Return of Optimus Prime: Part 1 (#3.29)}.
- Cheetor's line "Who died and made you Optimus?!" can be seen as a reference to how often characters named Optimus seem to sacrifice themselves and pass on their legacy to another leader.
- Botanica is the only plant-based Transformer ever to have existed. Besides that, she is the only Transformer to have two differently colored eyes.
- No toy of Botanica was ever produced, even though she is a major character in the series.
- Thrust clearly, albeit very quickly flips off Optimus Primal with his middle finger, to which he responds with an annoyed and displeased face.
- The end of this episode is the only time Megatron's big floating head transforms. Strangely, it seems to bear a resemblance to Megatron's earlier Predacon ship, the Darksyde.
- Silverbols and Nightscream make a reference to the popular board game Monopoly as they say, rather randomly, "Do not pass 'Go!'" "Do not collect $200!".
- Although Obsidian and Strika are said to be the most famous generals in Cybertron's history, and have won thousands of wars together, this episode marks their very first appearance (not counting one of Optimus Primal's earlier visions), and they are in fact brand new characters.
