The Andromeda Ascendant is a fictional starship in the television series Gene Roddenberry's Andromeda.

The ship began her life in the Newport News Orbital Shipyards above Earth, where her keel was laid in CY 9768. Construction proceeded without a hitch right through the delivery and installation of the Headwaters of Invention Mark VIII Slipstream engines in CY 9772. The Andromeda is the tenth Glorious Heritage-class heavy cruiser, High Guard ship of the line, from the days of the old Systems Commonwealth. Andromeda and her captain, Dylan Hunt (played by Kevin Sorbo) were frozen in the event horizon of a black hole for 300 years before being rescued by the crew of the Eureka Maru in CY 10087 (approx 5167 CE).

The ship has an artificial intelligence (AI). Andromeda appears to the crew in three formats: on the two-dimensional monitors; as a three-dimensional holographic projection; and as the avatar Rommie (played by Lexa Doig). In the High Guard, AIs are considered officers as part of their own crew. An avatar is a humanoid representation of an intelligence, and Andromeda has the above mentioned holographic and android avatars that represent the personality and physical representation of the ship's AI, in this case in the form of a human female. The ship's engineer, Seamus Zelazny Harper (played by Gordon Michael Woolvett), built an android as her second avatar, which can interact with the holographic avatar and the monitors, and also travel, walk and act outside the ship. The monitor and hologram manifestations are commonly referred to in fandom as "Core" and "Logic", respectively.

The ship is equipped with a slipstream drive for FTL (faster than light) travel.

Andromeda is somewhat unusual among starships as it is clearly implied that she has an emotional attachment to Captain Hunt. This is a variation on the idea of captains being in love with their ships, implied for centuries and extensively used by Roddenberry in Star Trek.