| Himself - Former Representative | played by Billy Tauzin |
| Michigan (segment "Under the Influence") | played by John Dingell |
| Himself - Representative | played by John Dingell |
| Himself - Executive Director | played by Ron Pollack |
| Families USA (segment "Under the Influence") | played by Ron Pollack |
| Medicare (segment "Under the Influence") | played by Richard Foster (XXIV) |
| Himself - Chief Actuary | played by Richard Foster (XXIV) |
| Himself - President (segment "Under the Influence") | played by George Bush |
| Herself - Correspondent (segment "Not So Perfect a Match") | played by Lesley Stahl |
| Denver (segment "Not So Perfect a Match") | played by Mitch Morrissey |
| Himself - District Attorney | played by Mitch Morrissey |
| Himself - Head of DNA Analysis | played by Angelo Della Manna |
| Alabama (segment "Not So Perfect a Match") | played by Angelo Della Manna |
| Himself - Attorney (segment "Not So Perfect a Match") | played by Stephen Mercer (II) |
| Herself - Detective (segment "Not So Perfect a Match") | played by Sue Hickman (II) |
| Himself - Wrongfully Accused of Murder (segment "Not So Perfect a Match") | played by Darryl Hunt (II) |
| Himself - Correspondent (segment "The Age of Warming") | played by Scott Pelley |
| Himself - Scientist (segment "The Age of Warming") | played by Gino Casassa |
| Himself - Biologist (segment "The Age of Warming") | played by Wayne Trivelpiece |
| Herself - Biologist (segment "The Age of Warming") | played by Sue Trivelpiece |
| Himself - Climate Change Institute (segment "The Age of Warming") | played by Paul Mayewski |
| Himself - Commentator (segment "Andy Rooney") | played by Andrew Rooney |