- Movie Goof (continuity error): Whenever Jeff was shot at the end of the movie, the Mayans shot him with 2 arrows, then during the next scene it shows he has been shot with 3 arrows.
- Movie Goof (errors in geography): The northern Yucatan Peninsula where this movie is supposed to be set is flat. There are some small hills in some areas but nothing extremely hilly like shown in several shots.
- Ben Stiller was involved with this film because he is a friend of novelist / screenwriter Scott B. Smith.
- SPOILER: Even though the novel and the screenplay were written by the same person, the deaths of the characters are switched around. In the film, Stacy cuts her knee and the plants start growing inside her. She ends up killing Eric and begs for the others to kill her. In the book, it's Eric who cuts his knee, and he kills Mathias. In the film, Mathias breaks his back and later gets his legs cut off. In the novel, this happens to Pablo (who is called Dimitri in the film). In the film, Jeff is killed by the Mayans trying to save Amy so she can escape. In the novel, Jeff is killed by the Mayans trying to escape after Amy has been killed by the plants during the night. In the novel, Stacy is the last survivor. She commits suicide in front of the ruins to warn off others who might find the ruins. But the plants make her body disappear. In the novel, Amy is the first character to die. In the film, she is the only one who survives and, unlike any of the characters in the novel, she actually manages to escape.
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