Jacqueline Bisset, who plays Domino's mother (renamed Sophie Wynn in the film), actually knew Domino Harvey's real life mother Paulene Stone. They knew each other from their time as models and had worked together.
Mickey Rourke initially turned down the role of Ed as he felt the script was weak and wanted to take part in Guy Ritchie's Revolver (2005/I), which was shooting at the same time. However, he gave in when director Tony Scott re-wrote the part with Rourke specifically in mind.
Tony Scott met Domino ten years previously to make a movie of her life but only nailed the script when Richard Kelly (II) came on board in 2002, creating the whole DMV plot to tie everything together.
Mickey Rourke's character, Ed Moseby, is based on real-life bounty hunter Ed Martinez, while Delroy Lindo's character, Claremont Williams III, is based on real-life bail-bondsman Celes King III, Domino Harvey's real boss. Both men were used as technical advisors on the film.
Richard Kelly (II) was asked to write the screenplay after Tony Scott read the script for Southland Tales.
Tony Scott first heard about Domino Harvey when his business manager Neville Shulman sent him an article about her from the British newspaper 'The Mail on Sunday'.
The rights to Domino Harvey's life story was secured at the price of $500K.
The scene where Domino, Ed, and Choco are standing outside Claremont's office with their guns is a reference to a photo of Domino Harvey and Ed Martinez outside Celes King III's office, that was in the newspaper article where Tony Scott first heard about Domino. The photo was also printed on the cover page of all drafts of the film's shooting script.
Domino Harvey died from an accidental overdose of fentanyl on 27 June 2005, months before the release of the film, which was subsequently dedicated to her. Tony Scott and Mickey Rourke were among the people who attended her funeral.
The character of Alf was inspired by the real life driver of Domino Harvey, Ed Martinez and Choco. According to Harvey, he was a man from Afghanistan whom they referred to as 'The Afghani' as they could not pronounce his name.
Tony Scott came up with the idea to set the climax of the film at the Stratosphere tower after shooting Beat the Devil (2002) in Las Vegas.
The word "fuck" and all of its derivatives are said 123 times in the movie.
The inspiration for Domino's goldfish Sammy came from actress Dakota Fanning, who told Tony Scott during the making of Man on Fire about her goldfish who had died.
Multiple key off-screen lines of dialog are actually voiced by picture editor Tony Ciccone. Ciccone recorded the lines while editing in post production. Director Tony Scott was impressed enough with the performances of the one-time actor to keep them in the final film.
Ron Jeremy appeared in one scene as a bail jumping drug dealer who was chased by Domino and Ed, but was cut from the film.
Charles Paraventi originally auditioned for the role of Raul Chavez. Tony Scott did not think he was right for the part and instead cast him as Howie Stein.
Thanks to Gusmano Cesaretti, Michael Mann's regular collaborator, Tony Scott managed to get on screen real-life gang bangers from 18th Street Gang in East Los Angeles.
For Domino's Reality TV Show in the movie, the producers created a promo poster of the three hunters with Domino on the far right. Domino's mother said they'd only go for it if Domino was in the center. The final movie poster is the same as the reality poster, with Domino in the center.